Metabolic Coordination of Tumor Suppression
نویسندگان
چکیده
منابع مشابه
Tumor suppression
The tumor suppressor gene TP53 and its gene product—a veritable swiss Army knife of cellular regulation—have been the targets of intense study since their discovery in 1979. 1-3 indeed, a PubMed search for the term " p53 " retrieves more than 68 000 citations, and more than 100 physical or genetic interactions with TP53 have been identified to date. its importance in cancer biology was recogniz...
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15 صفحه اولSuppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo
Mutation of p53 occasionally results in a gain of function, which promotes tumor growth. We asked whether destabilizing the gain-of-function protein would kill tumor cells. Downregulation of the gene reduced cell proliferation in p53-mutant cells, but not in p53-null cells, indicating that the former depended on the mutant protein for survival. Moreover, phenformin and 2-deoxyglucose suppressed...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.219.4